Usability Engineering, Data Infrastructure, and Information System Design & Development

A major component within the Cardioproof project is the analysis of clinical requirements including data, content of use, clinical workflow, and data requirements gathered by other work packages. This data is then used with the goal of analysing and solving usability and workflow-related problems,which prevent the application of modelling and simulation methods in clinical practice.

Proof of model-based cardiovascular prediction in clinical settings


The rapid development of modelling and hardware tools promises an ability of a patient specific modelling of blood flow in a human blood circulation. Thanks to EU-funded projects, such as Virtual Human Project or e-Heart, the first modelling tools are available. We aim to prove the ability of modelling tools to work in clinical settings by a validation of modelling predictions for two groups of patients: patients with an aortic valve disease and patients with a narrowing of the aorta called coarctation that is a congenital heart disease.

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Virtual Stenting


Aortic coarctation is a narrowing of the aorta in the region of the transition between the aortic arch and the descending aorta where the fetal ductus arteriosus is joined. It occurs in about 7% of all congenital heart defects. The high afterload induced by the stenosis can lead to ventricular dysfunction and thus a major therapy goal is to remove the pressure gradient. According to the AHA Guidelines, balloon angioplasty with stenting is a minimally invasive recommended therapy for patients with a systolic pressure gradient of more than 20 mmHg (Feltes, et al. 2011). optimal stent placement is however a non-trivial task.


Physics developments and protocol optimisation at GOSH

Great Ormond Street Hospital (GOSH) is the biggest paedi- atric hospital in the UK and the Cardiac Unit is the big- gest paediatric congenital heart disease unit in Europe. Our centre for cardiovascular imaging at GOSH performed 1000 clinical scans and 500 research scans in 2013-2014 with a projected 50% increase in numbers for 2014-2015. In the MR (Magneto Resonance) Physics Development Group we augment the work of the Imaging Service at GOSH by significantly reducing scan times for routine imaging and increasing the numbers of children who can be scanned without anaesthesia. The Cardioproof protocol is extremely long with significant additional scanning required over and above routine clinical imaging. This may prolong scans times to over 1.5 hours, which is unacceptable to most patients in our population. Therefore, we have made a significant attempt to speed up the protocol by developing new accelerated sequences.

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CARDIOPROOF ‘s Bootstrapped Infrastructure

One of the central pillars of Cardioproof is the technical infrastructure that enables the safe hosting, transmission and analysis of the pa- tient data on which the project relies. Gnúbila, with consultation from clinical and technical partners, has put in place the first version of the infrastructure for the Cardioproof project. This infrastructure has been built on top on the ongoing FP7 project MD-Paedigree, as an extension to it, in order to make best use of time, effort and funding.

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