Lynkeus is an independent strategy consultancy, founded in 2000, which works to identify and promote the best cutting-edge technological solutions to complex socio- economic problems in a variety of areas related to technological applications in public policies, with a particular focus on European Framework Programme Integrated Projects in e-Health. Since 2005 Lynkeus has played leading roles in the conceptualisation, development and execution of major ICT for Health projects financed through the EC’s FP6 and 7. Starting with Health-e-Child( Lynkeus has been collaborating with leading European clinical, research and industrial institutions. This cooperation has expanded with the launch of two further projects: in 2010, the Sim-e-Child ( VPH STREP (with the addition of John Hopkins University in Baltimore and the American College of Cardiology to a core research team composed of some of Health-e-Child’s partners), and, in 2013, the MD-Paedigree VPH IP, comprising some of the former European and American partners, with the addition of several new ones. Besides playing a strategic role in supporting the coordination of all these projects, Lynkeus has specialised in Project Management, Dissemination and Exploitation.


Deutsches Herzzentrum Berlin, Hospital


The Deutsches Herzzentrum Berlin (German Heart Institute Berlin, DHZB) is one of Europe’s largest Heart Institutes. The research activities of the DHZB cover almost all emerging fields of cardiac diagnostic and therapy, which is reflected by more than 120 peer reviewed publications annually. One major research focus is on non-invasive cardiovascular imaging of patients in all age

groups (from infancy to late adulthood). Research of imaging based modelling has been successfully introduced in the past years in is currently applied in several clinical conditions (including heart failure in mitral and aortic valve disease, pulmonary stenosis, aortic coarctation). In addition modelling of blood flow in new valve substitutes is part of the DHZB research (EU FP7 “life valve” project) The imaging science group of the DHZB covers the full spectrum of cardiovascular research that ranges from the development of hard- and software, the conduction of small and large animal research, translational science and the lead in clinical multicentre studies.


UCL – University College of London – University – United Kingdom


UCL is a large academic university associated with one of the largest paediatric hospitals in Europe – Great Ormond Street Hospital for Children NHS Foundation Trust (GOSH). UCL has one of the largest cardiovascular imaging (echocardiography and MRI) department. The cardiovascular MR department is renowned for its research excellence and forms a crucial part of the UCL Institute of Cardiovascular Science research strategy. The department has a track record of developing novel imaging methods for the assessment of cardiac and vascular function, and has developed novel ways to image and analyse visceral and peripheral fat. Moreover it has been at the forefront of integrating engineering and computer modelling with imaging for the use in the development of safe implantation of cardiovascular devices and more generally, through the FP6 Health-e-Child project, for all treatments of congenital heart disease.


OPBG- Ospedale Pediatrico Bambino Gesù, Private Research Institution


The Bambino GesùPaediatric Hospital (OPBG) is a health care and research institution, specialised in paediatric and developing ages, part of the Italian National Healthcare System and widely recognised as referral centre for all paediatric specialties at national and international level. Thanks to its organization, structures, technologies and highly qualified health care professionals, it guarantees total coverage for all health care needs, including emergencies. OPBG’s Research Areas are: immunology, oncology-haematology, genetics and rare diseases, multifactorial diseases and complex phenotypes; clinical-technological innovations; organizational and management models; regenerative medicine; clinical innovations and trials; management innovations; integrated information networks; biobank; technological platform.

Principal Investigator: Marcello Chinali

EU Grant: € 382.400


Fraunhofer- Gesellschaft zur Förderung der angewandten Forschung e.V., Research Institution


Fraunhofer MEVIS, Institute for Medical Image Computing (FME) was founded in 1995 as an independent non-profit research and development centre in the neighbourhood of the University of Bremen and is now part of Fraunhofer-Gesellschaft. The research focuses on computerassistance for medical diagnosis and therapy based on modern imaging, quantitative image analysis and visualisation, computer-aided teaching and training. FME is dedicated to achieving practically useful solutions to clinically relevant problems. This includes computer-assisted diagnostics, surgical risk analysis and planning based on biophysical modelling and numerical simulation, and intraoperative support including liver surgery, neurosurgery, and thoracic surgery.

Since 2009, image-based analysis and simulation of blood flow is an important research topic. FME has a strong background in the field of image-based therapy planning for interventions and surgery. Within the BMBF-funded project Virtual Liver that aims at creating a dynamic, multiscale model of the human liver, blood flow simulations are performed on different scales. FME has a worldwide net of collaborations with researchers from cardiovascular imaging groups as well as clinical sites and several nationally funded projects in the field of cardiovascular diagnosis and therapy support.


SAG – Siemens Ag– Industry – Germany


Siemens AG is a global electronics and electrical engineering company, operating in industry, energy, healthcare, and infrastructure & cities. Innovation is Siemens’ major growth and productivity driver. Its Corporate Technology (CT) division (3,000 researchers, >55,000 active patents, is a world leader among technology company research networks. Siemens CT offers an exciting interdisciplinary R&D environment to young people integrating them in highly qualified project teams of advanced researchers with academic degrees, engineers and technicians.

The participating Research Group, Image Analytics Germany, within the global Imaging and Computer Vision Technology Field in Siemens CT consists of 12 people and conducts research and development in medical imaging, machine learning, object and pattern recognition, medical decision support systems, and computer-assisted interventions.


ESI – ESI Group, Industry


ESI is a world leading software company with more than 1000 employees around the world, that specialises in the numerical simulation of prototype and manufacturing process engineering in applied mechanics. The key to ESI’s success is the use of realistic material physics, providing “as good as real” virtual solutions, in order to replace the lengthy trial and error processes on real prototypes.

ESI has developed an entire suite of coherent industry-oriented applications to realistically simulate a product’s behaviour during testing, to fine tune the manufacturing processes in synergy with the desired product performance, and to evaluate the environment’s impact on product usage. ESI’s product portfolio, which has been industrially validated and combined in multi-trade value chains, represents a unique collaborative, virtual engineering solution, enabling a continuous improvement on the virtual prototype. ESI is making substantial R&D efforts and forms partnerships with leading academic and research laboratories in order to offer state-of-the-art solutions. Consulting projects with strategic industrial partners as well as European R&D contracts exemplify ESI Group’s strong engineering knowledge and scientific expertise.


MUG- Medical University of Graz, University


The MUG comprises 16 Research Institutes, 23 Clinical Departments and a Center for Medical Research equipped with highly specialized core facilities as well as lab and office space. The number of employees is about 1700. Approx. 4500 students are enrolled in the study programmes (Human Medicine, Dentistry, Doctoral Programs) and post-graduate programs. The University runs internationally accredited PhD Programs in topics such as metabolic and cardiovascular diseases, inflammation, cancer, stem cells, aging of the brain and neuro-degeneration. The University has been participating in numerous EU-funded projects (FP5, 6 and 7) and acts as coordinator of various large research initiatives, among them also a project within the COMET funding line. The MUG runs one of the largest biobanks in Europe and plays a leading role in the European Union’s endeavour to build up a harmonized biobanking infrastructure across Europe.

The Computational Cardiology Lab (CCL) at the Institute of Biophysics develops integrated multi-scale computer models of bioelectric and mechanic activity of the heart. The underlying software stack CARP (Cardiac Arrhythmia Research Package), developed in cooperation with E. Vigmond (U. Bordeaux), is the worldwide leading software for cardiac modelling (in terms of usage in scientific publications), allowing to conduct highly complex in-silico experiments in a robust and efficient manner. Key methodological includes image-based unstructured FE mesh generation, the numerics of solving cardiac electrophysiology and mechanical deformation problems (domain decomposition methods, multigrid preconditioners, stiff ODE solvers), software engineering and high performance computing (strongly scalable algorithms, GP-GPUs).


GNUBILA MAAT France Sarl, Industry


Gnúbila France (ex maatG) is a consulting firm delivering ICT solutions and professional services axed on Grid and Cloud computing with a special emphasis on e-Health and Health Information Systems. Gnúbila France justifies of a rich expertise in the establishment and execution of multi-partner collaborations, which it has capitalized upon its involvement in several international initiatives. Gnúbila France is a member of the Spanish Gnúbila Technology group ( – for which it is managing the biomedical applications line. Gnúbila Technology, on a larger scale, provides cross-sectorial solutions including but not restricted to Information System, Customer Relationship Management and Data Integration for Public Administration, Financial Institutions and Small and Medium Enterprises. Gnúbila is implanted in Argonay in France, in Valencia in Spain and in Bucaramanga, in Colombia.

Gnúbila Technology, on a larger scale, provides cross-sectorial solutions including but not restricted to Information System, Customer Relationship Management and Data Integration for Public Administration, Financial Institutions and Small and Medium Enterprises. Gnúbila is implanted in Argonay in France, in Valencia in Spain and in Bucaramanga, in Colombia.


LSE- London School of Economics and Political Science, University


LSE Health and Social Care is a research centre within the London School of Economics & Political Science that brings together diverse disciplinary perspectives and cutting edge methods to tackle current and future challenges to health and social care in the UK, Europe and beyond. The Centre’s unique research base contributes to the LSE’s established world presence and reputation in health policy, health economics and demography. Its mission is to advance, transmit and sustain knowledge and understanding through the conduct of research, teaching and scholarship at the highest international standards, for the benefit of the international and national health policy community. Bringing together a core team of researchers and academics, LSE Health promotes and draws upon the multidisciplinary expertise of 30 staff members, 50 associated academics and a number of postgraduate students.

LSE is a specialist university with an international intake and a global reach. Its research and teaching span the full breadth of the social sciences, from economics, politics and law to sociology,

anthropology, accounting and finance. Founded in 1895 by Beatrice and Sidney Webb, the School has an outstanding reputation for academic excellence. 16 Nobel prize winners have been LSE staff or alumni. In 2008 LSE’s outstanding success in the Research Assessment Exercise confirmed it as a world leading research university. The School had the highest percentage of world leading research of any university in the UK, topping or coming close to the top of a number of rankings of research excellence.