Primary Objectives

  1. Conduct validation trials in patients with AVD or CoA that reflect a real-world approach by covering and comparing the complete spectrum of cardiovascular treatment
  2. Provide first data about comparative clinical and cost effectiveness of VPH approaches compared to conventional diagnostic and treatment algorithms
  3. Accelerate the deployment of CV VPH methods by improving their usability and interoperability in the clinical context

Assess the validity of methods developed in previous research (reuse of methods)

    • Computational fluid dynamics (CFD) models of the AV and the aorta including fluid-structure interaction
    • Biomechanical-electrophysiological model of the LV
    • Lumped heart model
    • Particle methods for blood flow

The methods’ validity is to be assessed for their accuracy to predict:

    • Immediate treatment outcome, enabling physicians to choose best timing and treatment options:
      • AVD trial: follow-up/medication vs. surgical valve reconstruction vs. surgical valve replacement (including the testing of different types of valve substitutes)
      • CoA trial: follow-up/medication vs. catheter based intervention (including the testing of different stenting strategies)
    • The evolution of the disease outcome in growing children with CoA.